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Microphysiological Systems Engineer

Becoming

Becoming

Software Engineering
San Francisco, CA, USA
Posted on Feb 23, 2026

About Becoming

Becoming is building Developmental Intelligence: AI for predicting how organisms change over time.

Most experimental systems fail when metabolic demands become too high. We are building systems that don’t — by combining engineered metabolic environments, sensing, control, and software into tightly integrated products that operate reliably over long time horizons.

Hardware is core to our platform. It must work continuously, predictably, and under real biological constraints.

The Role

We are hiring a Microphysiological Systems Engineer to design and own precision fluidic systems inside integrated hardware platforms.

This is not an academic chip-design role. You will build durable, scalable systems that operate reliably over extended periods.

You will define architecture, make tradeoffs, and own performance.

What You’ll Own

  • End-to-end ownership of fluidic subsystems within integrated hardware platforms
  • Fluidic architecture: channel geometry, flow control strategy, materials selection, sealing, and durability
  • Mass transport modeling and flow stability optimization
  • Integration with sensing, actuation, and control electronics
  • Design for long-duration operation under environmental constraints
  • Prototyping, validation, leak testing, and failure analysis
  • Debugging systems under continuous runtime, not short bench tests
  • Documentation, build processes, and standards that enable scaling

Who You Are

You are someone who:

  • Operates with high agency — you identify problems, define solutions, and execute
  • Takes end-to-end ownership of what you build
  • Brings high energy to complex, ambiguous engineering challenges
  • Acts with high integrity — you are honest about tradeoffs, risks, and failure modes
  • Communicates directly and clearly, especially when something won’t work
  • Is self-aware about your strengths and gaps, and proactively fills them
  • Thinks like a systems integrator, not a narrow specialist
  • Cares deeply about understanding systems at a first-principles level
  • Engineering degree or equivalent demonstrated depth
  • Experience designing and shipping custom fluidic systems
  • Strong first-principles understanding of fluid dynamics and mass transport
  • Experience integrating fluidic systems with mechanical and electrical platforms
  • Demonstrated ownership of systems operating under real-world constraints
  • Ability to operate without rigid scaffolding or pre-validated vendor platforms

Strong Signals

  • Precision flow systems or perfusion environments
  • Integration into robotics or complex instrumentation platforms
  • Systems designed for continuous or long-horizon runtime
  • Clear examples of reliability tradeoffs you’ve made and owned
  • Bias toward simplicity, maintainability, and durability
  • Competitive salary and meaningful equity
  • Full benefits
  • High-trust, high-ownership environment
  • Rapid growth in scope and responsibility